In the year of 1502, Mengli Giray destroyed the city of Saray and attacked to the Golden Horde Khanate with his last raids. Then, he gave an end to his policy of collaboration with Moscow. These two states that emerged as a result of the decline of the Golden Horde State were involved in a great struggle in order to establish dominion in the Golden Horde regions. Mehmed Giray I. (1514-1523) became the khan in the capacity as kalgay in the last years of his father and he started to organise severe attacks against the Moscow princedom. His brother, Sahib Giray was enthroned as the sovereign of Kazan (1521). He defeated the army of Belski over the river of Oka and advanced towards Moscow and set fire to the environs of the city. In the following year, he captured Astrahan. Moscow Bey accepted to pay an annual tax (tıyış).
When he had provided the strongest position of his khanate, Mehmed Giray was killed upon a raid of Nogay people while he was returning from the military expedition to Astrahan and his works were destroyed. Pursuant to these events, the Crimean Khanate was involved in a severe struggle with the Moscow State on the ruins and inheritance of the Golden Horde State in the basin of Volga River. These struggles should be divided into two periods: The first period extends towards the events in which the former Kazan Khan, Sahib Giray (1532-1551) ascended the throne of the Crimean Khanate; and the second period extends towards the events when the Moscow Tsar, Ivan IV established his dominion in the basin of Volga (1552-1556).